LIPO-6X

LIPO-6X by Nutrex is the first and only advanced fat burner using a new and superior MULTI-PHASE™ technology featuring two capsules in one. This unique MULTI-PHASE™ technology combines rapid release, liquid-capsule delivery with controlled-release, inside-capsule technology. What this means is that LIPO-6X is the only fat burner that has multiple release phases— both fast and extended— for all-day results.
Key Product Highlights:
Synephrine HCL
Synephrine activates beta-3 adrenoreceptors and therefore, displays a lipolytic and thermogenetic capacity as it boosts norepinephrine levels.1 By consuming synephrine prior to workouts, you enhance fat breakdown (whilesparing muscle) with subsequent utilization of body fat for energy.2 Synephrine has demonstrated its efficacyas an ephedra alternative for revving your metabolism without altering heart rate or blood pressure.3-4Synephrine further acts as a powerful appetite suppressant, curbing hunger pains during a calorie-restricted diet.
Yohimbine
Yohimbine is just right for the thermogenetic concoction in LIPO-6X to help induce lipolysis (the burning ofstored fat)5-6without the side effects from other fat burners (i.e., increased heart rate, increased blood pressure,anxiety).7-8 Furthermore, yohimbine induces excitatory effects, improving elements of cognitive function andprimarily alertness.9
Acacia Rigidula
Acacia rigidula is a blackbrush shrub that contains a combination of amines (Phenylethylamine N-methyl-beta-Phenylethylamine, Hordenine, Tyramine) that provide thermogenic effects to increase metabolism, stimulating the mind and body for the ideal exercise enhancer.10
Phenylethylamine HCL/N-Methyl-B-Phenylethylamine (Thyroid-Stimulating Proprietary Matrix)
This synthetic combination is designed to mimic the effects of natural acacia rigidula. As an efficacious and very clean central nervous-stimulant and mood enhancer,11-12 phenylethylamine can increase your metabolism and optimize stored fat utilization for energy— without the side effects you can get from other stimulants (i.e., nervousness, anxiety, headaches). Furthermore, phenylethylamine has been shown to improve mood quickly, without producing tolerance to supplementation.13
Tyramine HCL
Tyramine is a complementary ingredient to further induce thermogenesis and get those extra calories burning. Tyramine induces the release of norepinephrine, increasing metabolic rate and promoting energy expenditure.14-16
Hordenine
Hordenine is a naturally-occurring alkaloid from a variety of grains and grasses, with the ability to liberate norepinephrine stored in your body to promote a faster metabolism and rid you of unwanted body fat.17-18 The Hordenine presented in LIPO-6X is of a pure and powerful synthetic origin.
Caffeine Anhydrous
Caffeine provides a variety of enhancements for the neuromuscular system, including increases in the secretion of catecholamines19-21 and calcium release from the sarcoplasmic reticulum.22 With its capacity to optimize skeletal muscle contraction from augmented neuromuscular transmission,23 caffeine has demonstrated its ability to enhance strength gains and increase work volume.24-26 While allowing you to work harder, caffeine also boosts your metabolism, assisting in body-fat loss while recruiting lean body mass.27-28 Caffeine also improves mental alertness and mood function, optimizing your level of focus through your workouts or fatigue-battling tasks.29-30 By providing caffeine in its anhydrous form, you're getting a more pure, synthetic form for maximal potency.
Synthetic 99% Guggulsterones Z&E 1:1
E- and Z-Guggulsterones are the bioactive compounds of Guggul (Commiphora Mukul) that have purported benefits for lowering LDL cholesterol and triglycerides.31-32 Guggulsterones also have the capacity to rev your metabolism by increasing the overall thyroid hormone activity, with significant influence on triiodothyronine (T3) hormone (thyroid regulator).33-35 By supplementing with guggulsterones, you are also inhibiting excessive inflammatory responses that occur with regular exercise.36
References:
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- Kalman DS, Colker CM, Shi Q, Swain MA. Effects of a weight-loss aid in healthy overweight adults: double-blind, placebo-controlled clinical trials. Curr Ther Res, 2000; 61(4):199-205.
- Colker CM, Kalman DS, Torina GC, Perlis T, Street C. Effects of Citrus aurantium Extract, Caffeine, and St. John's Wort on body fat loss, lipid levels, and mood states in overweight healthy adults. Curr Ther Res, 1999; 60(3):145-153.
- Pensak SR, Jann MW, Cold JA, Hon YY, Desai HD, Gurley BJ. Seville (sour) orange juice: synephrine content and cardiovascular effect in normotensive adults. J Clin Pharmacol, 2001, 41(10):1059-63.
- Moro CO, Basile G. Obesity and medicinal plants. Fitoterapia, 2000, 71 Suppl 1:S73-82.
- Kreider RB, Almada AL, Antonio J, Broeder C, Earnest C, Greenwood M, Incledon T, Kalman DS, Kleiner SM, Leutholtz B, Lowery LM, Mendel R, Stout JR, Willoughby DS, Ziegenfuss TN. ISSN exercise & sport nutrition review: research and recommendations. Sport Nutr Rev J, 2004, 1(1):1-44.
- Ostojic SM. Yohimbine: the effects on body composition and exercise performance in soccer players. Res Sports Med, 2006; 14(4):289-99.
- McCarty MF. Pre-exercise administration of yohimbine may enhance the efficacy of exercise training as a fat loss strategy by boosting lipolysis. Med Hypotheses, 2002; 58(6):491-5.
- Morgan CA 3rd, Southwick SM, Grillon C, Davis M, Krystal JH, Charney DS. Yohimbine-facilitated acoustic startle reflex in humans. Psychopharmacology (Berl), 1993; 110(3):342-6.
- Clement BA, Goff CM, Forbes DA. Toxic amines and alkaloids from Acacia Rigidula. Phytochemistry, 1998; 49(5):1377-1380.
- Parker EM and Cubeddu LX. Comparative effects of amphetamine, phenylethylamine and related drugs on dopamine efflux, dopamine uptake and mazindol binding. J Pharmacol Exp Ther, 1988, 245(1):199-210.
- Xie Z, Miller GM. Beta-phenylethylamine alters monoamine transporter function via trace amine-associated receptor 1: implication for modulatory roles of trace amines in brain. J Pharmacol Exp Ther, 2008, 325(2):617-28.
- Sabelli H, Fink P, Fawcett J, and Tom C. Sustained antidepressant effect of PEA replacement. J Neuropsychiatry Clin Neurosci, 1996, 8:168-171.
- Holmes JC and Fowler NO. Cardiac effects of Tyramine. Circulation Research, 1962; 11:364.
- Brandao F, Rodrigues-Pereira E, Monteiro JG, Davidson R. A kinetic study of the release of noradrenaline by tyramine. Nauryn-Schmiedebergs Arch Pharm, 1981; 318(2):83-87.
- Schafers RF, Poller U, Ponicke K, Geissler M, Daul AE, Michel MC, Brodde OE. Influence of adrenoceptor and muscarinic receptor blockade on the cardiovascular effects of exogenous noradrenaline and of endogenous noradrenaline released by infused tyramine. Naunyn-Schmiedeberg's Archives of Pharmacology, 1997; 355(2):239-249.
- Hapke HJ and Strathmann W. Pharmacological effects of hordenine. [Article in German] Dtsch Tierarzti Wochenschr, 1995; 102(6):228-32.
- Frank M, Weckman TJ, Wood T, Woods WE, Tai CL, Chang SL, Ewing A, Blake JW, Tobin T. Hordenine: pharmacology, pharmokinetics and behavioural effects in the horse. Equine Vet J, 1990; 22(6):437-41.
- Costill, D L, Dalsky, GP, Fink, WJ. Effects of caffeine ingestion on metabolism and exercise performance. Med Sci Sports Exerc, 1978, 10:155-158.
- Graham, TE. Caffeine and exercise: Metabolism, endurance, and performance. Sports Med, 2001, 31:786-807.
- Ivy, JL, Costill, DL, Fink, WJ, Lower, R. W. Influence of caffeine and carbohydrate feedings on endurance performance. Med Sci Sports Exerc, 1979, 11:6-11.
- Lopes, JM, Aubier, M, Jardim, J, Aranda, JV, and Macklem, PT. Effect of caffeine on skeletal muscle function before and after fatigue. J Appl Physiol, 1983, 54:1303-1305.
- Williams, JH. Caffeine, neuromuscular function and high-intensity exercise performance. J Sports Med Phys Fitness, 31:481-489. 1991.
- Kalmar, JM, and Cafarelli, E. Effects of caffeine on neuromuscular function. J Appl Physiol, 1999, 87:801-808.
- Beck, TW, Housh, TJ, Schmidt, RJ, Johnson, GO, Housh, DJ, Coburn, JW, and Malek, MH. The acute effects of a caffeine-containing supplement on strength, muscular endurance, and anaerobic capabilities. J Strength Cond Res, 2006, 20(3):506-510.
- Astorino, TA, Rohmann, RL, Firth, K. Effect of caffeine ingestion on one-repitition maximum muscular strength. Euro J of Appl Physiol. 2008. 102(2):127-132.
- Acheson, KJ, Zahorska-Markiewicz, B, Pittet, P, Anantharaman, K, and Jequier, E. Caffeine and coffee: their influence on metabolic rate and substrate utilization in normal weight and obese individuals. American Journal of Clinical Nutrition, 1980. Vol 33, 989-997.
- Dulloo, AG, Geissler, CA, Horton, T, Collins, A, Miller, DS. Normal caffeine consumption: influence on thermogenesis and daily energy expenditure in lean and postobese human volunteers. Am J Clin Nutr, 1989. 49:44-50.
- Lieberman HR, Tharion WJ, Shukitt-Hale B, Speckman KL, Tulley R. Effects of caffeine, sleep loss and stress on cognitive performance and mood during U.S. Navy SEAL training. Sea-Air-Land. Psychopharmacology (Berl), 2002, 164(3):250-61.
- Haskell CF, Kennedy DO, Wesnes KA, Scholey AB. Cognitive and mood improvements of caffeine in habitual consumers and habitual non-consumers of caffeine. Psychopharmacology (Berl), 2005, 179(4):813-25.
- Nityanand S, Srivastava JS, Asthana OP. Clinical trials with guglipid. A new hypolipidaemic agent. J Assoc Physicians India, 1989; 37(5):323-8.
- Urizar NL and Moore DD. GUGLIPID: a natural cholesterol-lowering agent. Annu Rev Nutr, 2003; 23:303-13.
- Panda S and Kar A. Guggulu (Commiphora mukul) induces triiodothyronine production: possible involvement of lipid peroxidation. Life Sci, 1999; 65(12):PL137-41.
- Panda S and Kar A. Guggulu (Commiphora mukul) potentially ameliorates hypothyroidism in female mice. Phytother Res, 2005; 19(1):78-80.
- Kreider RB, Almada AL, Antonio J, Broeder C, Earnest C, Greenwood M, Incledon T, Kalman DS, Kleiner SM, Leutholtz B, Lowery LM, Mendel R, Stout JR, Willoughby DS, Ziegenfuss TN. ISSN exercise & sport nutrition review: research and recommendations. Sport Nutr Rev J, 2004, 1(1):1-44.
- Deng R. Therapeutic effects of guggul and its constituent gugglesterone: cardiovascular benefits. Cardiovasc Drug Rev, 2007; 25(4):375-90.



